Chris Masterjohn

Harvard's Dr. Anna Mandinova shares groundbreaking insights into skincare. She explains how most creams only provide temporary hydration, the importance of sunscreen, and why tanning beds are dangerous. Mandinova emphasizes the crucial role of diet, particularly carotenoids, in skin health. She also discusses how advanced treatments like microneedling and laser therapies can lead to lasting skin improvements. Learn how science-backed skincare can truly rejuvenate your skin for the long term.

Obesity doesn't cause type 2 diabetes simply by storing excess fat. When the body can't store more fat, excess energy leads to insulin resistance. Hydrogen sulfide (H2S) plays a key role in fat storage and insulin sensitivity. This article explains how H2S helps expand adipose tissue and prevent diabetes, but too much H2S can impair fat loss. By optimizing H2S production through diet and nutrient intake, it’s possible to balance fat storage, insulin sensitivity, and diabetes risk.

D-lactate is traditionally considered a product of gut bacteria, but humans also produce it endogenously through the methylglyoxal pathway. This article delves into its critical roles in energy metabolism, gluconeogenesis, and its impact on neurological conditions like Parkinson’s disease. It also introduces the concept of the "D-lactate shuttle," a newly coined term for a unique metabolic pathway that helps balance NAD+ levels and mitochondrial function under specific conditions.

Urolithin A, marketed as “exercise in a pill,” claims to rejuvenate mitochondria and boost strength without exercise. With endorsements from experts like Dr. Mark Hyman, its benefits sound revolutionary. But what’s the science behind it? This article explores the claims of urolithin A, including its potential to improve strength and endurance without physical activity. It also examines the cost, mechanisms, and who might truly benefit from this supplement.

Creatine is often celebrated for its muscle-boosting benefits, but its importance extends far beyond athletic performance. Acting as a vital energy source for your mitochondria, creatine supports brain function, vision, digestion, and skin health. This comprehensive guide delves into how creatine distributes ATP throughout your cells, the natural limits of its synthesis, and why modern diets often fall short.

Iron overload is well-known for causing liver damage, diabetes, and aging acceleration, but genetic predispositions also increase manganese levels. This article explores the complex interplay between iron and manganese overload, emphasizing the need for careful dietary management. With tips on maintaining an iron-to-manganese ratio and practical dietary advice, it provides a comprehensive guide to managing both minerals for optimal health and preventing toxicity.

Niacin, nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN) are popular for boosting NAD+ and promoting longevity. However, a recent study raises concerns about the cardiovascular risks associated with high doses of niacin and its metabolites, particularly 4PY. This article explores the latest findings, emphasizing the potential risks of elevated 4PY levels and the need for caution in supplementing with niacin and NAD+ precursors, especially at high doses.

In the world of mitochondrial health, MK-4 is a missing link. While CoQ10 is widely recognized, MK-4 plays a unique role in supporting mitochondrial function and optimizing cellular energy. This article delves into the structural and functional parallels between CoQ10 and MK-4, highlighting their complementary roles in the respiratory chain. It also emphasizes the importance of incorporating MK-4 into supplementation regimens for comprehensive mitochondrial support and improved overall health.