The Most Reliable Longevity Supplements from Siim Land
DoNotAge is a supplement brand that has gained a reputation for offering high-quality products. Known for their 100% pure ingredients, which undergo third-party testing for purity and low heavy metal content, the company has also been involved in funding longevity research. In this article, we dive into an unbiased review of the various supplements offered by DoNotAge, exploring the scientific studies behind each ingredient and its claimed effects.
The Role of CEN6 in Longevity
One of the flagship products from DoNotAge is the CEN6 Activator. CEN6 refers to a family of proteins involved in the regulation of metabolism, DNA repair, energy production, and circadian rhythms. While many of the common CENs, like CEN1, CEN2, and CEN3, have not shown significant life-extending effects, CEN6 is different. A study from 2012 revealed that overexpressing CEN6 extended the lifespan of male mice by 10–15.8%, though not for females. However, this effect was also linked to low IGF1 levels, which are associated with extended lifespan in animals. It’s important to note that while CEN6 may improve metabolic health, more research is needed, particularly in humans, to confirm its potential in longevity.
NMN and NR: The NAD-Boosting Supplements
Another popular supplement offered by DoNotAge is NMN (Nicotinamide Mononucleotide), which, alongside NR (Nicotinamide Riboside), is known for its ability to raise NAD+ levels. NAD+ is crucial for cellular function, and increasing its levels has been shown to have potential anti-aging effects. Studies have shown that both NMN and NR raise NAD+ levels in a dose-dependent manner, with doses up to 1,000 mg being safe. However, clinical studies on the life-extending effects of these compounds in humans are still limited. Both supplements have demonstrated some positive effects in terms of inflammation reduction and other health markers, but consistent life extension effects remain to be proven.
Hyaluronic Acid and Skin Anti-Aging
DoNotAge also offers Hyaluronic Acid, a compound well-known for its ability to maintain skin hydration. With age, our bodies produce less hyaluronic acid, contributing to wrinkles and loss of skin elasticity. Studies have shown that a daily dose of 120 mg of hyaluronic acid can improve skin condition and reduce wrinkles. DoNotAge’s formula, which includes 200 mg of hyaluronic acid per capsule, is sufficient to provide these benefits. The anti-aging effects on skin are well-supported by scientific research, making it a promising addition to any longevity regimen.
Collagen for Skin Health
As we age, our body’s collagen production declines, leading to wrinkles and sagging skin. Collagen supplementation has been widely studied, and numerous trials have demonstrated its effectiveness in improving skin hydration, reducing wrinkles, and reversing signs of skin aging. DoNotAge provides 10 grams of hydrolyzed collagen peptides per scoop, an optimal dose supported by clinical evidence. This supplement is especially beneficial for those looking to maintain youthful skin as they age.
Creatine for Muscle and Cognitive Function
While creatine is best known for its muscle-building properties, recent studies suggest that it can also benefit cognitive function, particularly in older adults. DoNotAge includes 5 grams of creatine per scoop in their supplements, which is a suitable dose for both improving muscle mass and supporting brain health. Clinical research has shown creatine’s potential to improve cognition, particularly in older individuals, making it a valuable addition to a longevity supplement stack.
Calcium Alpha-Ketoglutarate (AKG) for Longevity
AKG is another compound frequently featured in longevity supplements. This molecule plays a key role in energy metabolism, particularly in the citric acid cycle, and its levels decline with age. Research suggests that supplementing with AKG could extend lifespan and improve health span, with some studies showing up to a 20% extension of lifespan in animals. DoNotAge offers 400 mg of AKG per capsule, but for optimal results, users may need to take 2–3 capsules. While more research is required in humans, AKG shows promise in supporting metabolic health.
Trimethylglycine (TMG) for Homocysteine Reduction
Trimethylglycine (TMG) is a methyl donor that supports methylation and helps lower homocysteine levels, an amino acid linked to cardiovascular diseases and dementia. Research indicates that doses of up to 4 grams of TMG per day can significantly reduce homocysteine levels without raising cholesterol. DoNotAge offers 500 mg of TMG per capsule, which is effective for maintaining healthy homocysteine levels, though higher doses may be needed for maximum benefit.
CoQ10 for Heart Health and Energy
CoQ10 (Coenzyme Q10) is another key ingredient in DoNotAge’s supplement lineup. This compound supports mitochondrial function and has been shown to improve energy levels and heart function. Studies have also found that CoQ10 supplementation can reduce fatigue and improve glycemic control, particularly in diabetic individuals. DoNotAge provides 100 mg of CoQ10 per capsule, which is the optimal dose for energy support. However, while CoQ10 has shown some heart health benefits, more research is needed to establish its role in cardiovascular disease prevention.
Berberine for Blood Sugar Regulation
Berberine is often referred to as "nature’s metformin" due to its ability to lower blood sugar levels. Clinical trials have shown that berberine effectively reduces blood glucose in people with diabetes, though it is not as effective as metformin. Additionally, berberine has been shown to improve lipid metabolism and support weight management. DoNotAge includes 500 mg of berberine per capsule, an appropriate dose based on clinical evidence.
Omega-3 Fatty Acids for Heart and Brain Health
DoNotAge offers a high-quality Omega-3 supplement with 750 mg of Omega-3s per softgel, including EPA, DHA, and other Omega-3s. Omega-3 fatty acids are well-documented for their cardiovascular and cognitive benefits, with studies showing that they reduce the risk of heart disease, improve brain function, and enhance insulin sensitivity in diabetics. The triglyceride form of Omega-3s used by DoNotAge is more bioavailable, making it an excellent choice for those looking to support heart and brain health.
Resveratrol and Sulforaphane: Anti-Aging and Anti-Inflammatory
Resveratrol has long been associated with longevity due to its antioxidant properties, but recent studies have shown it may not extend lifespan, even in animals. Nevertheless, it remains effective in lowering cholesterol and blood sugar in people with diabetes and obesity. DoNotAge includes 500 mg of trans-resveratrol per scoop. On the other hand, sulforaphane, found in cruciferous vegetables, is a powerful compound that activates antioxidant defense pathways. DoNotAge’s Sulforaphane Boost supplement is designed to increase sulforaphane levels, offering potential benefits in managing diabetes, inflammation, and Alzheimer’s disease.
Sure Sleep for Better Rest
Finally, Sure Sleep is another DoNotAge product designed to improve sleep quality. It contains a combination of magnesium glycinate, tryptophan, and other ingredients to promote relaxation and support deep sleep. Quality sleep is essential for longevity, and this supplement can help those who struggle with getting adequate rest.
Final Thoughts on DoNotAge Supplements
Overall, DoNotAge offers a wide range of supplements that have shown promise in supporting longevity. While some ingredients have solid evidence from clinical trials, others, such as CEN6 and sulforaphane, require more research to confirm their benefits in humans. Nevertheless, the brand’s commitment to quality, third-party testing, and high-purity ingredients makes it a reliable choice for anyone looking to optimize their health and longevity. With a solid foundation of evidence for most of its products, DoNotAge offers a compelling option for those interested in extending their lifespan and improving their overall well-being.