The One Supplement to Rule Them All - NOVOS Core Review
NOVOS Core is a supplement designed to target all the Hallmarks of Aging. With 12 key ingredients, this supplement has generated attention from major media outlets such as Forbes and The Wall Street Journal. It has also been popular among those in the Rejuvenation Olympics, but like any supplement, it’s essential to understand the scientific evidence supporting its claims. In this detailed review, I’ll go over the individual ingredients in NOVOS Core, the studies behind them, and the overall efficacy of the product.
NOVOS Core and Longevity
NOVOS Core combines several ingredients believed to work synergistically, meaning the whole could be greater than the sum of its parts. The idea is that the formulation targets aging from multiple angles, including DNA repair, inflammation reduction, and metabolic optimization. One pre-print mouse study showed that daily NOVOS supplementation extended the lifespan of mice by 20% over controls, comparable to a highly effective senolytic intervention. This effect was seen even when the supplementation started at an older age. However, it’s important to note that the study has not yet been peer-reviewed, so more research is needed to confirm these results in humans.
Another piece of evidence comes from a small pilot study on humans. This case study, which involved 12 participants, showed a reduction in their epigenetic speed of aging by an average of 6.1%, with some participants experiencing a reduction of up to 14%. While promising, the study is not large enough to draw definitive conclusions, and further research is needed. Still, this data does point to the potential for NOVOS Core to have an impact on aging markers.
A peer-reviewed study in 2024 explored NOVOS Core’s effects on DNA damage in human skin cells. In this study, skin cells were exposed to a DNA-damaging agent after being treated with NOVOS. The results suggested that NOVOS Core had a preventive effect against DNA damage, which is a promising sign. However, the study’s reliance on DNA damage markers instead of direct DNA damage measurements means that the findings should be interpreted with caution.
Key Ingredients in NOVOS Core
Let’s now take a deeper look at the individual ingredients in NOVOS Core and their research-backed benefits.
Vitamin C plays a crucial role in regulating genomic stability and reducing chronic inflammation, both of which are Hallmarks of Aging. While antioxidants like Vitamin C can be beneficial, there is some evidence suggesting that excessive doses may impair muscle growth and mitochondrial function after exercise. Nonetheless, Vitamin C’s role in collagen synthesis for skin, hair, and nails is well-established.
Magnesium is another essential ingredient in NOVOS Core. Magnesium is linked to reducing the risk of many chronic inflammatory conditions, and it plays a central role in most of the Hallmarks of Aging. Magnesium deficiency is a significant concern as it can impact several bodily functions, including mitochondrial energy production. The magnesium dose in NOVOS Core is sufficient to help maintain daily magnesium intake, but it may not be high enough to fully counteract deficiencies for some individuals.
Glycine is a key amino acid involved in collagen turnover, which is important for skin and joint health. Glycine supplementation has been shown to extend the lifespan of mice, and it also lowers inflammation, one of the Hallmarks of Aging. However, the 2 grams of glycine in NOVOS Core may be insufficient for optimal collagen turnover, as studies suggest that 10 grams a day may be ideal. Additionally, glycine works well in combination with NAC, another important ingredient for supporting antioxidant activity.
Calcium Alpha-Ketoglutarate (AKG) has been shown to extend lifespan and improve health span in animal models. AKG helps maintain genomic stability and supports mitochondrial function. However, while human studies on AKG’s benefits are limited, there is some evidence linking AKG supplementation with improved recovery and wound healing. The dose of 1100 milligrams of AKG in NOVOS Core aligns with the doses used in animal studies but may need more evidence to confirm its effects in humans.
Glucosamine Sulfate, a well-known joint health supplement, is included in NOVOS Core at a dose of 1000 milligrams. There is mixed evidence on the efficacy of glucosamine, particularly for osteoarthritis. Some studies show moderate improvements, while others suggest larger doses of glucosamine may be needed for maximum benefits. Additionally, glucosamine has been linked to lower mortality risk and improved cardiovascular health, further enhancing its value in a longevity supplement.
Rhodia Rosea, an adaptogen, helps regulate the body’s stress response. It has been shown to support mitochondrial function and improve stress resilience, making it an important ingredient for overall health. At 300 milligrams per dose, the amount in NOVOS Core is consistent with clinical studies showing benefits for fatigue and stress management.
Theanine, another amino acid, supports cognitive function and stress relief. Studies have shown that theanine improves attention, executive function, and sleep quality, especially in middle-aged and older adults. With 150 milligrams per dose, NOVOS Core provides a solid amount of theanine to support these benefits.
Hyaluronic Acid, which decreases with age, is included in NOVOS Core to support skin hydration and elasticity. Some studies show that hyaluronic acid supplementation can reduce wrinkles and improve skin condition, particularly when taken over a longer period. The dose in NOVOS Core is 100 milligrams, which may be enough to offer some benefits, though higher doses have shown more significant effects.
Fistin is a compound that targets senescent cells, which accumulate as we age. Fistin has been shown to extend lifespan in animal models and reduce inflammation. While studies on its human applications are still lacking, its potential for eliminating senescent cells makes it a promising addition to a longevity supplement.
Ginger Root, a well-known herb with anti-inflammatory properties, can help reduce body fat and improve blood sugar regulation. While the dose in NOVOS Core is lower than the amounts used in clinical studies, ginger’s inclusion adds further anti-aging benefits through its antioxidant and anti-inflammatory effects.
Peros Bean, which is derived from berries and grapes, improves DNA repair and lowers inflammation. While clinical trials are still limited, Peros Bean has shown promise in some studies for its potential to aid in longevity by improving DNA function and mitochondrial health.
Lithium Aspartate, a low dose of lithium, has shown neuroprotective effects and may help slow cognitive decline. While more research is needed to determine its preventive effects on aging, lithium has been linked to a reduced risk of dementia and cognitive impairment, making it a valuable ingredient in NOVOS Core.
Conclusion
Overall, NOVOS Core contains a variety of ingredients with solid research backing their individual benefits for longevity, inflammation reduction, and DNA protection. However, some ingredients appear to be underdosed for optimal benefits, such as glycine and glucosamine sulfate. The combination of these ingredients in the product may still have a synergistic effect that provides greater value than each ingredient alone. While early studies on NOVOS Core show promising results, more research and larger clinical trials are needed to confirm its effectiveness in humans. With its well-chosen ingredients and reasonable dosing, NOVOS Core earns an overall rating of 4 out of 5. It has the potential to support a longer, healthier life, but further studies will be crucial to fully assess its long-term benefits.