#Supplements

Can supplements extend lifespan? The National Institute on Aging's 20-year study reveals 9 compounds with proven effects in mice. From rapamycin’s promising benefits to glycine’s dietary role, explore what might translate to human longevity and how personalized approaches can make a difference.

A 2024 JAMA study questions multivitamin benefits, but flawed data leaves doubts. In contrast, the COSMOS trial shows cognitive gains even with basic multivitamins. Dr. Kara Fitzgerald shares why a personalized approach often works best, but multivitamins can still play a vital role. Learn how to make informed supplement choices for better health outcomes.

A groundbreaking study utilizing data from the National Health and Nutrition Examination Survey (NHANES) reveals a significant association between dietary Omega-3 fatty acid intake and reduced accelerated biological aging, termed PhenoAgeAccel. Analyzing over 20,000 adults, researchers found that higher Omega-3 consumption correlates with slower biological aging, particularly up to a threshold of 1.103 grams per day.

Dive into Dave's transformative approach to health and wellness, where advanced biohacks meet smart living technologies. From mastering balance with indoor slacklining to harnessing Hyperbaric Oxygen Therapy and stem cell treatments for injury recovery, Dave shares his proactive strategies for optimal health. Explore his meticulous supplementation regimen, including nicotinamide riboside and B vitamins, and his high-tech smart home setup that automates lighting, climate, and daily routines.

Micronutrients, including essential vitamins and minerals, are crucial for your body’s optimal function. From energy production to immune support, they play a significant role in maintaining health. This article explores how nutrients like B-vitamins, calcium, magnesium, and antioxidants can enhance your well-being. Discover how optimizing your intake, beyond just meeting the minimum requirements, can contribute to a longer, healthier, and more vibrant life.

This article delves into the interplay between diet and health, examining the impact of red meat, fruits, and vegetables on cancer risk, the benefits of time-restricted eating, and the role of supplements like creatine and caffeine. It also addresses common misconceptions about plant-based foods, autophagy, and the carnivore diet, offering insights into how personalizing your approach to diet and supplementation can optimize both physical and mental health.

At 61, Dave Pasco is redefining aging. Ranked among the top in the Rejuvenation Olympics, he’s slowed his biological aging to just 0.66 years per calendar year. Unlike billionaires relying on costly protocols, Dave’s success stems from smart nutrition, stress management, and biohacking tools like PMF mats, BFR bands, and red light therapy. Discover how his balanced, practical approach to health and longevity is inspiring a global community to live longer and better lives.

After decades of battling chronic illness, including mercury poisoning and mold toxicity, Mark Hyman turned to the upgraded PK Protocol. By using phospholipid exchange therapy, which repairs damaged cell membranes and detoxifies the body, they regained vitality and mental clarity. This innovative approach, backed by comprehensive testing, offers hope for those suffering from chronic conditions. Learn how the protocol improved health, energy, and brain function in dramatic ways.

D-lactate is traditionally considered a product of gut bacteria, but humans also produce it endogenously through the methylglyoxal pathway. This article delves into its critical roles in energy metabolism, gluconeogenesis, and its impact on neurological conditions like Parkinson’s disease. It also introduces the concept of the "D-lactate shuttle," a newly coined term for a unique metabolic pathway that helps balance NAD+ levels and mitochondrial function under specific conditions.

Longevity science often highlights NAD precursors like NMN and NR for boosting cellular health, but do they truly extend lifespan? Dr. Peter Attia and Andrew Huberman delve into the data, discussing NAD's role, the impact of supplements, and FDA rulings. They emphasize that while supplements may offer minor benefits, lifestyle changes—exercise, sleep, and nutrition—are the true drivers of health and longevity. Dive into their analysis and learn why focusing on foundational habits matters most.

Urolithin A, marketed as “exercise in a pill,” claims to rejuvenate mitochondria and boost strength without exercise. With endorsements from experts like Dr. Mark Hyman, its benefits sound revolutionary. But what’s the science behind it? This article explores the claims of urolithin A, including its potential to improve strength and endurance without physical activity. It also examines the cost, mechanisms, and who might truly benefit from this supplement.

Aging reduces vitamin D efficiency, making supplementation crucial. Recent research reveals most need over 2,000 IU daily to maintain healthy levels. Learn how vitamin D supports bone, muscle, immunity, and epigenetics—and why personalized dosing and testing are essential for your health journey. Optimize your vitamin D for a healthier, longer life!

Creatine is often celebrated for its muscle-boosting benefits, but its importance extends far beyond athletic performance. Acting as a vital energy source for your mitochondria, creatine supports brain function, vision, digestion, and skin health. This comprehensive guide delves into how creatine distributes ATP throughout your cells, the natural limits of its synthesis, and why modern diets often fall short.

In our final newsletter edition, we summarize Dr. Matt Walker's insights on the biology of sleep, effective strategies to enhance sleep quality, and answers to your top sleep-related questions. From managing negative thoughts and finding the best sleep positions to understanding sleep patterns in older adults and menopause, get actionable tips to transform your nightly rest. Plus, learn about key supplements that can aid your sleep journey.

Magnesium is essential for various bodily functions, from DNA repair to brain health and cardiovascular support. Inadequate magnesium intake can accelerate aging, raise disease risk, and impair muscle function. This article explores magnesium’s role in aging, disease prevention, and its impact on sleep, brain health, and blood pressure. Find out why this often-overlooked nutrient is vital for optimal health and longevity.

Iron overload is well-known for causing liver damage, diabetes, and aging acceleration, but genetic predispositions also increase manganese levels. This article explores the complex interplay between iron and manganese overload, emphasizing the need for careful dietary management. With tips on maintaining an iron-to-manganese ratio and practical dietary advice, it provides a comprehensive guide to managing both minerals for optimal health and preventing toxicity.

Explore how simple lifestyle changes, such as addressing micronutrient deficiencies and incorporating vigorous exercise, can optimize aging. Dr. Rhonda Patrick explains how these strategies help improve longevity by boosting brain health, reducing inflammation, and enhancing cardiovascular function. Learn how regular exercise, combined with key supplements, can slow aging and reduce the risk of chronic diseases, offering a holistic approach to a healthier life.

Niacin, nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN) are popular for boosting NAD+ and promoting longevity. However, a recent study raises concerns about the cardiovascular risks associated with high doses of niacin and its metabolites, particularly 4PY. This article explores the latest findings, emphasizing the potential risks of elevated 4PY levels and the need for caution in supplementing with niacin and NAD+ precursors, especially at high doses.

In the world of mitochondrial health, MK-4 is a missing link. While CoQ10 is widely recognized, MK-4 plays a unique role in supporting mitochondrial function and optimizing cellular energy. This article delves into the structural and functional parallels between CoQ10 and MK-4, highlighting their complementary roles in the respiratory chain. It also emphasizes the importance of incorporating MK-4 into supplementation regimens for comprehensive mitochondrial support and improved overall health.